Future perspectives: What lies ahead for Neuronal Ceroid Lipofuscinosis research?

Progress is being made in all aspects of Neuronal Ceroid Lipofuscinosis (NCL) research, resulting in many recent advances. These advances encompass several areas that were previously thought intractable, ranging from basic science, through to a better understanding of the clinical presentation of different forms of NCL, therapeutic development, and new clinical trials that are underway. Increasing numbers of original NCL research papers continue to be published, and this new sense of momentum is greatly encouraging for the field. Here, we make some predictions as to what we can anticipate in the next few years

Quality and Safety in Population Health

Why has the volume to value movement become stuck as organizations struggle with downside risk and unaccomplished goals? How do the traditional models of quality improvement and patient safety work in population health? When you are no longer changing one person’s condition, or fixing one organization’s opportunities for improvement, what do you use? This webinar will describe the translation of concepts, methods, and tools from organizational improvement to population health management and provide ideas for simple approaches to create results. Objectives Review the volume to value movement Discuss traditional models of quality improvement and patient safety in population health Describe the translation of concepts, methods, and tools from organizational improvement to population health management Provide ideas for simple approaches to create results Presentation: 56:5

Measuring velocity and turbulent diffusivity in wall-flow filters using compressed sensing magnetic resonance

Gas-phase compressed sensing magnetic resonance methods have been used to image gas flow velocity and turbulent diffusivity in wall-flow particulate filters. Two-dimensional magnetic resonance velocity imaging was used to observe the local distribution of gas velocity in the direction of superficial flow (z) in the entrance and exit regions of the filter at an in-plane spatial resolution of 140 µm (x) × 140 µm (y) and 140 µm (x) × 390 µm (z) perpendicular to and parallel with the direction of superficial flow, respectively. Images were acquired in 14 min. Three-dimensional images of the turbulent diffusivity were acquired at a spatial resolution of 280 µm (x) × 280 µm (y) × 1250 µm (z) for channel Reynolds numbers, Rec, of 210, 360, 720 and 1140. These data provide evidence of regions of turbulence inside the filter that has not been predicted by earlier numerical simulations. For Rec = 1140, a three-dimensional velocity image was also obtained at the same spatial resolution as the image of turbulent diffusivity; the data acquisition time was 2 h. Co-registration of these two images enables visualisation of the spatial extent and magnitude of these two characteristics of the flow field.JDC would like to thank Johnson Matthey and the EPSRC for a CASE award (award reference 1628588)

An experimental study of amphibole stability in low-pressure granitic magmas and a revised Al-in-hornblende geobarometer

We report new experimental data on the composition of magmatic amphiboles synthesised from a variety of granite (sensu lato) bulk compositions at near-solidus temperatures and pressures of 0.8–10 kbar. The total aluminium content (Al$^\text{tot}$) of the synthetic calcic amphiboles varies systematically with pressure ($\small \textit{P}$), although the relationship is nonlinear at low pressures (<2.5 kbar). At higher pressures, the relationship resembles that of other experimental studies, which suggests of a general relationship between Al$^\text{tot}$ and P that is relatively insensitive to bulk composition. We have developed a new Al-in-hornblende geobarometer that is applicable to granitic rocks with the low-variance mineral assemblage: amphibole + plagioclase (An$_{15–80}$) + biotite + quartz + alkali feldspar + ilmenite/ titanite + magnetite + apatite. Amphibole analyses should be taken from the rims of grains, in contact with plagioclase and in apparent textural equilibrium with the rest of the mineral assemblage at temperatures close to the haplogranite solidus (725 ± 75 °C), as determined from amphibole–plagioclase thermometry. Mean amphibole rim compositions that meet these criteria can then be used to calculate $\small \textit{P}$ (in kbar) from Al$^\text{tot}$ (in atoms per formula unit, apfu) according to the expression: $P$ (kbar) = 0.5 + 0.331(8) × Al$^\text{tot}$ + 0.995(4) × (Al$^\text{tot}$)$^2$ This expression recovers equilibration pressures of our calibrant dataset, comprising both new and published experimental and natural data, to within ±16 % relative uncertainty. An uncertainty of 10 % relative for a typical Al$^\text{tot}$ value of 1.5 apfu translates to an uncertainty in pressure estimate of 0.5 kbar, or 15 % relative. Thus the accuracy of the barometer expression is comparable to the precision with which near-solidus amphibole rim composition can be characterised.BHP Billiton, Royal Society (Wolfson Research Merit Award), California Institute of Technology (Moore Scholarship

Extended density matrix model applied to tall barrier quantum cascade lasers

Quantum cascade lasers (QCLs) are promising sources of terahertz (THz) radiation that have applications such as security and medical screening. While optical output power has recently exceeded 1 W, their highest operating temperature is currently limited to ~200 K due to mechanisms such as thermal back filling and non-radiative phonon emission between lasing states. Another possible cause of performance degradation is parasitic leakage currents over barriers into continuum states as subband electron temperatures increase with lattice temperature. Novel designs with new injection schemes remain an intensive research area and new efforts are being made assuming that barrier heights no longer need to be constant. A possible advantage of this is using tall barriers to reduce the leakage current, and in this work we present a theoretical study of recent experimental evidence supporting this. Interface roughness (IFR) scattering scales with the conduction band discontinuity squared and the calculations also assume a typical correlation length Λ and root mean roughness value Δ which are related to growth quality of the individual sample. We take typical values of Λ=60 Å and Δ=3 Å for these parameters. The QCL gain and current output characteristics are calculated using an extended density matrix solver which models transport through the injection barrier coherently. We obtain similar current and gain values at resonance for both structures, indicating that the experimentally observed reduction in current density could be accredited to the reduction of parasitic current leakage. Additionally, this work attempted a similar design with all AlAs barriers which did not lase and it was conjectured that this was due to excessive IFR scattering as well as increased susceptibility to monolayer fluctuations with thinner layers. Our model, which accounts for the lifetime broadening in the gain calculation, confirms that modifying the IFR parameters to Λ=100 Å and Δ=1 Å (i.e. unrealistically sharp interfaces) leads to a significant improvement in performance as shown in Figure 1. We extend this work by proposing designs which aim to balance leakage current reduction and excessive scattering to achieve higher operating temperatures

Open-source bandstructure models of interdiffusion, impurity and exciton states for the QWWAD v1.4 simulation suite

The vast majority of high-quality software for simulating semiconductor nanostructures (e.g., [1]) is supplied under a proprietary license and its source code cannot be studied, modified or redistributed by its users. The open-source project, Quantum Wells, Wires and Dots (QWWAD) [2] is a free, non-commercial community-focused resource, which accompanies the new 4th edition of the eponymous textbook [3]. Previously described features in QWWAD include numerical Schrodinger/Poisson solvers in generic 1D potentials [e.g., Fig. 1(a)], quasi-analytical and empirical pseudopotential calculations of the band-structure in quantum wires and dots, and scattering calculations for interactions with impurities, phonons, interface roughness, alloy disorder and carrier–carrier processes. We describe new tools, included in the latest release (QWWAD v1.4), for modelling the perturbed quantum-confined states within 2D heterostructures resulting from interdiffusion, impurities and excitonic contribution